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Quick Comparison of HPE ProLiant ML350 Gen10 Server vs HPE ProLiant ML110 Gen10 Server at a Glance

The server comparison table provides a quick overview of the key specifications and key features for HPE ProLiant ML350 Gen10 Server and HPE ProLiant ML110 Gen10 Server Let’s take a look at the comparison table below.

Features
HPE ProLiant ML350 Gen10 Server

HPE ProLiant ML350 Gen10 Server

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HPE ProLiant ML110 Gen10 Server

HPE ProLiant ML110 Gen10 Server

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Server Type / Form Factor

  • Type: Tower Server (convertible to rack mount with optional kit)

  • Form Factor: 4U chassis (rackable takes up ~5U)

  • Socket: Dual socket (supports up to 2 Intel Xeon Scalable CPUs)

  • Type: Tower Server (upgradeable to rack mount with optional kit)

  • Form Factor: 4.5U Tower

  • Socket: Single socket (supports 1 Intel Xeon Scalable CPU)
Processor (CPU)

  • Processor Family: Intel Xeon Scalable Processors (1st or 2nd Gen)

  • Supported Cores per CPU: 6 to 28 cores (e.g., Xeon Bronze to Platinum models)

  • L3 Cache: Up to 38.5 MB per processor

  • Max Frequency: Up to ~3.5 3.9 GHz depending on CPU model

  • Max TDP: Up to 205 W

  • Processor Family: Intel Xeon Scalable (1st and 2nd Generation)

  • Core Options: 4, 6, 8 or up to 14 cores (e.g. Xeon Silver 4210, 4210R, Gold 5222)

  • Max Frequency: Up to ~3.6 GHz

  • Max TDP: Up to ~110 W

  • Memory Capacity (per socket): Up to 192 GB with 6 × 32 GB RDIMM
Memory (RAM)

  • Type: HPE DDR4 SmartMemory (RDIMM, LRDIMM, or Intel Optane DC Persistent Memory)

  • DIMM Slots: 24 (12 per processor)

  • Maximum Capacity: Up to 3 TB using 128 GB DIMMs (RDIMM/LRDIMM)

  • Speed: 2666 or 2933 MT/s depending on CPU generation

  • Memory Protection: Advanced ECC, Memory Lock step, Online Spare

  • Type: DDR4 HPE SmartMemory (RDIMM only)

  • DIMM Slots: 6 slots (1 DIMM per channel across 6 memory channels)

  • Max Capacity: 192 GB (6 × 32 GB at 2933 MT/s for Gen2 CPUs)

  • Speed: Up to 2933 MT/s (depending on CPU model)
Storage

  • Front Drive Bays:

    • Up to 12 × LFF (3.5") SAS/SATA hot plug

    • Or up to 24 × SFF (2.5") SAS/SATA/NVMe hot plug



  • Expansion Options: Additional bay trays may support NVMe or hybrid drive layouts

  • RAID Controllers: HPE Smart Array P408i a SR, P816i a SR, E208i a, P824i p, etc.

  • Boot Options: Optional M.2 boot module or Smart Array controller-based boot

  • Drive Bays: Up to 8 × LFF (hot plug SATA/SAS) or 16 × SFF (hot plug)

  • Controller: HPE Smart Array S100i SR Gen10 (software RAID), or optional P408i p, E208i p HW controllers

  • Boot Options: Optional M.2 module or SATA/eMMC boot (UEFI only)
Expansion / Connectivity

  • PCIe Slots: Up to 8 PCIe 3.0 slots in tower chassis for GPU, networking or HBA

  • Networking: Embedded 4 × 1 GbE NIC; optional Flexible LOM (OCP-style mezzanine) available

  • PCIe Slots: 5 × PCIe 3.0 slots (mix of x16 and x8 slots)

  • Networking: Embedded dual-port 1 GbE (Intel 332i); optional FlexibleLOM mezzanine for higher-throughput NICs
Redundancy & Reliability

  • Power Supplies: Standard 500 W or 800 W non hot plug PSU; optional redundant 500 W or 800 W Flex Slot PSUs

  • Cooling: Standard 4 fans; optional redundant fan cage for GPU or NVMe heavy configs

  • Security Features: TPM 2.0 module support, iLO Secure Boot, chassis padlock and bezel lock

  • Power Supply: 350 W or 550 W ATX PSUs; optional 800 W Flex Slot hot plug PSU

  • Cooling: Standard 2 non hot plug fans; optional redundant fan kit recommended for high RPM drives or SAS SSDs

  • Security: Silicon Root of Trust, UEFI Secure Boot, Secure Recovery, Runtime Firmware Validation
Operating System Support

  • Microsoft Windows Server 2016 / 2019 / 2022

  • Red Hat Enterprise Linux (RHEL)

  • SUSE Linux Enterprise Server (SLES)

  • VMware ESXi (vSphere 6.7 U3, 7.x, 8.x)

  • Other: Ubuntu, Oracle Linux, Citrix XenServer

  • Microsoft Windows Server 2016 / 2019 / 2022

  • Red Hat Enterprise Linux (RHEL)

  • SUSE Linux Enterprise Server (SLES)

  • VMware ESXi (vSphere 6.7 U3, 7.x, 8.x)

  • ClearOS, CentOS, Ubuntu, Oracle Linux
Security Features

  • Silicon Secured Boot: iLO 5 system configuration lock, BIOS advisor, secure recovery

  • Encryption: TPM 2.0 support, secure erase, firmware rollback, AES/3DES encryption

  • iLO 5 Security: Configurable server lock, BIOS Advisor, security dashboard

  • TPM 2.0 Support: Optional FIO module

  • Firmware Security: Secure Boot, Firmware rollback, Runtime Validation
Management & Monitoring

  • Integrated Lights Out (iLO 5): Full remote console, firmware updates, health monitoring

  • Management Tools: HPE Intelligent Provisioning, OneView, InfoSight

  • API Support: Redfish, RESTful, IPMI 2.0, SNMP v3

  • Embedded: HPE iLO Standard with Intelligent Provisioning

  • Optional Licenses: iLO Advanced, iLO Advanced Premium Security Edition

  • Tools: Active Health System, iLO RESTful API, OneView Standard, iLO Amplifier Pack
Warranty & Support

  • Standard Warranty: 3 Year Parts, 3 Year Labor, 3 Year Onsite (Next Business Day)

  • Optional Services: HPE Foundation Care, Proactive Care, Pointnext Tech Care

  • Standard: 3 Year Parts, 3 Year Labor, 3 Year Onsite (Next Business Day)

  • Service Options: HPE Pointnext Tech Care, Foundation Care, Proactive Care

Key Features Comparison

Powerful Scalability:
Powered by Intel® Xeon® Scalable processors, the ML350 Gen10 offers robust, enterprise-level performance, making it an ideal choice for organizations with growing data needs.
Flexible Expansion Options:
Supports a broad range of storage configurations, from SATA HDDs to high-speed NVMe SSDs, with the capability to add up to 24 drive bays and 12 DIMM slots for versatile storage and memory expansion.
Enhanced Security and Reliability:
Features HPE’s Silicon Root of Trust technology to safeguard firmware against threats, along with robust redundancy features like dual power supplies to minimize downtime.
Advanced Management with HPE iLO 5:
HPE Integrated Lights-Out (iLO 5) simplifies server management with remote monitoring and diagnostic tools, making it easier to maintain and secure your IT infrastructure.
Energy Efficient Design:
Optimized for low power consumption, the ML350 Gen10 helps reduce operational costs, making it a cost-effective solution for high-performance needs.
Tower or Rack Mount Flexibility:
With the ability to be configured as a tower or rack-mount server, it’s adaptable to various deployment environments, from data centers to office setups.
Cost-Effective Performance
Powered by Intel® Xeon® Scalable processors, the ML110 Gen10 provides enterprise-grade performance at a budget-friendly price, making it an excellent choice for small to medium businesses.
Compact Tower Design
Its compact, quiet tower design is ideal for small offices and remote branch environments, saving valuable space without compromising performance.
Flexible Storage Options
Supports up to 8 LFF (Large Form Factor) or 16 SFF (Small Form Factor) drive bays, enabling businesses to choose storage configurations that suit their workloads, from HDDs to SSDs.
Enhanced Security Features
Equipped with HPE’s Silicon Root of Trust, protecting your server against firmware-level threats and ensuring data integrity across operations.
Energy Efficient and Quiet Operation
Designed to reduce power consumption and operate quietly, making it ideal for in-office deployments where energy efficiency and low noise are essential.
Simplified Management with HPE iLO 5
HPE’s Integrated Lights-Out (iLO) 5 provides easy remote management, streamlining server maintenance, monitoring, and security for IT administrators.

HPE ProLiant ML350 Gen10 Server vs HPE ProLiant ML110 Gen10 Server : Which should I choose?

Choosing the right server is a critical decision for any business, and comparing HPE ProLiant ML350 Gen10 Server and HPE ProLiant ML110 Gen10 Server gives you clear insights into which solution aligns best with your IT requirements. These servers are built for high performance, but they may differ in areas such as processor capacity, memory, storage, and scalability, making a side-by-side comparison easy.

This direct comparison helps you quickly identify the strengths and limitations of each server, which helps you determine which model best supports your workloads, applications, and long-term IT goals. By evaluating them together, you can make a smarter investment that ensures reliability and efficiency for your business.

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