Quick Comparison of HPE ProLiant Compute DL380 Gen12 vs Lenovo ThinkSystem SR650 V4 at a Glance

The server comparison table provides a quick overview of the key specifications and key features for HPE ProLiant Compute DL380 Gen12 and Lenovo ThinkSystem SR650 V4 Let’s take a look at the comparison table below.

Features	HPE ProLiant Compute DL380 Gen12 View Check the Price	Lenovo ThinkSystem SR650 V4 View Check the Price
Server Type / Form Factor	Type:Enterprise Rack Server Form Factor: 2U Rack Socket: Dual?socket (supports 1 or 2 Intel Xeon 6 processors)	Type: Enterprise Rack Server Form Factor: 2U Rack Socket: Dual-socket (2x Intel Xeon 6 processors)
Processor (CPU)	Processor Family: Intel Xeon 6 Scalable Processors Max Sockets: 2 Cores per Socket: Up to 144 cores Max Speed: Up to 3.9 GHz (varies by processor model) Memory Channels: 8 channels per processor	Processor Family: Intel Xeon 6 (6700/6500-series P-cores, Granite Rapids-SP) Max Sockets: 2 Max Cores per Socket: Up to 86 cores Max TDP: Up to 350 W per processor Socket Type: LGA 4710
Memory (RAM)	Memory Type: HPE DDR5 Smart Memory (RDIMM) DIMM Slots: 32 DIMM slots (16 per processor, 2 DIMMs per channel) Maximum Capacity: Up to 8 TB (with 256 GB modules) Maximum Speed: Up to 6400 MT/s at 1DPC (depends on CPU and DIMM population) Memory Protection: Advanced ECC, online spare, mirroring, combined channel (lockstep)	Memory Type: TruDDR5 (RDIMM, 3DS RDIMM, MRDIMM) DIMM Slots: 32x TruDDR5 RDIMMs + 16x MRDIMMs Maximum Capacity: Up to 8 TB Speed: Up to 6400 MHz (RDIMM), 8000 MHz (MRDIMM) Protection: Advanced ECC, RAS features
Storage	Front Drive Options: Up to 36 EDSFF E3.S NVMe drives Additional Drive Options: Up to 24 SFF bays (SAS/SATA/NVMe) LFF Bays: Up to 12 LFF bays (SAS/SATA) Max Internal Storage: 550.8 TB using 36 x 15.3 TB EDSFF NVMe Alternative Capacity: 480 TB using LFF SAS/SATA SSDs in 12+4+4 configuration RAID Support: HPE Smart Array controllers (RAID 0, 1, 5, 6, 10, 50, 60 – depending on controller)	Front Drive Bays: 24x 2.5" SAS/SATA/NVMe, 32x E3.S NVMe, or 12x 3.5" bays Mid Drive Bays: Up to 8x 2.5" SAS/SATA/NVMe Rear Drive Bays: Up to 8x 2.5" or 4x 3.5" SAS/SATA/NVMe Boot Drives: Up to 2x M.2 SATA/NVMe with RAID RAID Support: VROC NVMe SW RAID (0,1,5,10), PCIe RAID/HBA
Expansion / Connectivity	PCIe Slots: Multiple PCIe 5.0 slots (including up to four PCIe x16 full-height, full-length slots) OCP Slots: Up to two front OCP 3.0 slots for high-speed NICs or accelerators Networking: OCP 3.0 FlexibleLOM (choices of 1/10/25/100GbE) GPU Support: GPU-accelerated configurations and GPU-performance kits available for AI and HPC workloads	PCIe Slots: Up to 10x PCIe Gen5 slots OCP Slots: 2x OCP 3.0 slots Networking: OCP adapters, PCIe 10/25/100/200 GbE GPU Support: Up to 10x SW GPUs or 2x DW GPUs
Redundancy & Reliability	Power: Redundant hot-plug power supplies (various wattages and efficiency grades) Cooling: Redundant hot-plug fans; optional direct-liquid cooling-compatible designs Storage: Hot-swap drive bays and RAID-based redundancy options Availability Features: HPE-engineered reliability, service-level-ready architectures	Power: Dual redundant AC/DC PSUs (Platinum/Titanium efficiency) Cooling: Lenovo Neptune Core/Air technology, redundant fans Reliability: Six nines uptime, hot-swap components
Operating System Support	Microsoft Windows Server Red Hat Enterprise Linux (RHEL) SUSE Linux Enterprise Server (SLES) VMware ESXi Canonical Ubuntu Oracle Linux	Microsoft Windows Server Red Hat Enterprise Linux (RHEL) SUSE Linux Enterprise Server (SLES) VMware ESXi
Security Features	Silicon Root of Trust Secure Boot, Secure Start Intel TME (Total Memory Encryption) Firmware and Runtime Integrity Monitoring UEFI-managed encryption and privilege-separation controls Industry-standard compliance (ACPI 6.5, PCIe 5.0, PXE, Wake-on-LAN)	Lenovo ThinkShield security suite Silicon Root of Trust Secure Boot and fTPM 2.0 Federated directory security
Management & Monitoring	HPE iLO 7: Embedded management for remote console, BIOS setting, firmware updates, and alerts HPE Compute Ops Management: AI-driven operations dashboard and lifecycle automation APIs: RESTful / Redfish-based interfaces for integration with third-party tools	Lenovo XClarity Controller: Embedded management XClarity One: AI-driven analytics APIs: Redfish APIs for automation
Warranty & Support	Standard Warranty: 3 Years Parts, 3 Years Labor, 3 Years Onsite (varies by region and contract) Optional Support: HPE Pointnext, Foundation Care, Proactive Care, and custom SLAs	Standard Warranty: 3 Years Customer Replaceable Unit, Onsite NBD 9x5 Optional Support: Premier Support, TruScale Infrastructure Services

Key Features Comparison

High Performance Compute

The HPE ProLiant Compute DL380 Gen12 is a 2U rack server built on Intel Xeon 6 processors, supporting up to two processors with up to 144 cores per socket, enabling higher instructions per clock and up to significantly higher performance versus prior generations for demanding compute workloads

Large, High Speed Memory Capacity

It supports up to 8 TB of HPE DDR5 Smart Memory across 32 DIMM slots (16 per processor), with speeds up to 6400 MT/s at 1 DIMM per channel, delivering substantial headroom for virtualization, databases, and analytics

Flexible High-Speed Storage Options

The server offers multiple front-drive configurations including up to 36 EDSFF E3.S NVMe drives, 24 SFF bays, or 12 LFF bays, with maximum internal storage capacities reaching 550.8 TB using 36 x 15.3 TB EDSFF NVMe drives.

Advanced PCIe 5.0 Expansion & GPU Support

Powered by PCIe Gen5, the DL380 Gen12 provides up to four PCIe x16 full-height slots plus riser-based expansion, improving I/O throughput and latency; the platform also supports front OCP NICs and GPU-accelerated options, including GPU-performance kits for optimized thermal and power delivery.

Next-Generation Security & Firmware Protection

The server includes Intel Xeon 6 security features such as Intel TME (Total Memory Encryption) and HPE-specific protections such as Silicon Root of Trust, secure boot, and firmware integrity monitoring, helping safeguard data at boot, in-use, and at rest.

AI-Driven Management with HPE iLO 7

Equipped with HPE iLO 7, the DL380 Gen12 delivers embedded remote management, BIOS-level tuning, firmware updates, and Redfish-based APIs, while HPE Compute Ops Management provides AI-driven insights and lifecycle automation to simplify operations and reduce downtime.

Versatile Dual-Socket Intel Compute

The Lenovo ThinkSystem SR650 V4 is a 2U rack server powered by dual Intel Xeon 6 processors (up to 86 cores per socket, 350W TDP), optimized for virtualization, databases, hybrid cloud, analytics, and AI workloads with industry-leading reliability.

Ultra-High TruDDR5 Memory Capacity

Supports up to 8TB TruDDR5 memory across 32 DIMM slots (RDIMMs/3DS RDIMMs up to 6400MHz) plus 16x MRDIMMs up to 8000MHz, delivering massive scalability for memory-intensive enterprise applications.

Flexible High-Density Storage

Offers front: up to 24x 2.5" SAS/SATA/NVMe, 32x E3.S NVMe, or 12x 3.5", mid: 8x 2.5", rear: 8x 2.5" or 4x 3.5", plus 2x M.2 boot drives with RAID, supporting Direct NVMe and VROC/VMD for modern storage needs.

PCIe Gen5 & GPU Expansion

Provides up to 10x PCIe Gen5 slots plus 2x OCP 3.0, supporting up to 10x single-width GPUs or 2x double-width GPUs for AI training, inference, HPC, and graphics-intensive workloads.

Advanced Security & XClarity Management

Features Lenovo ThinkShield with silicon root of trust, secure boot, fTPM 2.0; XClarity Controller enables AI-driven predictive analytics, remote access, SSD failure analysis, and federated security.

Sustainable Cooling & Efficiency

Lenovo Neptune Core/Air cooling options deliver ENERGY STAR compliance, up to 3:1 rack consolidation, six nines uptime reliability, and reduced TCO for environmentally conscious deployments.

HPE ProLiant Compute DL380 Gen12 vs Lenovo ThinkSystem SR650 V4 : Which should I choose?

Choosing the right server is a critical decision for any business, and comparing HPE ProLiant Compute DL380 Gen12 and Lenovo ThinkSystem SR650 V4 gives you clear insights into which solution aligns best with your IT requirements. These servers are built for high performance, but they may differ in areas such as processor capacity, memory, storage, and scalability, making a side-by-side comparison easy.

This direct comparison helps you quickly identify the strengths and limitations of each server, which helps you determine which model best supports your workloads, applications, and long-term IT goals. By evaluating them together, you can make a smarter investment that ensures reliability and efficiency for your business.

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