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Quick Comparison of HPE ProLiant DL380 Gen10 Server vs HPE ProLiant ML350 Gen10 Server at a Glance

The server comparison table provides a quick overview of the key specifications and key features for HPE ProLiant DL380 Gen10 Server and HPE ProLiant ML350 Gen10 Server Let’s take a look at the comparison table below.

Features
HPE ProLiant DL380 Gen10 Server

HPE ProLiant DL380 Gen10 Server

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HPE ProLiant ML350 Gen10 Server

HPE ProLiant ML350 Gen10 Server

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Server Type / Form Factor

  • Type: Rack Server

  • Form Factor: 2U Rackmount

  • Socket: Dual socket (supports up to 2 processors)

  • Type: Tower Server (convertible to rack mount with optional kit)

  • Form Factor: 4U chassis (rackable takes up ~5U)

  • Socket: Dual socket (supports up to 2 Intel Xeon Scalable CPUs)
Processor (CPU)

  • Processor Family: Intel Xeon Scalable Processors (1st and 2nd Gen)

  • Supported Cores: 4 to 28 cores per CPU (e.g. Bronze 3200, Silver 4200, Gold 5200/6200 series)

  • Base Frequency: ~1.9 GHz to ~3.2 GHz depending on model

  • Max TDP: ~85 W to ~205 W per processor

  • Memory per Socket: Up to 1 TB (Silver/Gold) or up to 4.5 TB per socket (Large memory tiers with Optane)

  • Processor Family: Intel Xeon Scalable Processors (1st or 2nd Gen)

  • Supported Cores per CPU: 6 to 28 cores (e.g., Xeon Bronze to Platinum models)

  • L3 Cache: Up to 38.5 MB per processor

  • Max Frequency: Up to ~3.5 3.9 GHz depending on CPU model

  • Max TDP: Up to 205 W
Memory (RAM)

  • Type: DDR4 HPE SmartMemory (RDIMM, LRDIMM, DC Persistent Memory)

  • DIMM Slots: 24 slots (12 per processor, 6 channels each)

  • Max Capacity:

    • Up to 2.0 TB using RDIMM @ 2933 MT/s

    • Up to 3.0 TB using LRDIMM @ 2933 or 3200 MT/s

    • Up to 4.5 TB per socket using Intel Optane Persistent Memory (select SKUs)

  • Type: HPE DDR4 SmartMemory (RDIMM, LRDIMM, or Intel Optane DC Persistent Memory)

  • DIMM Slots: 24 (12 per processor)

  • Maximum Capacity: Up to 3 TB using 128 GB DIMMs (RDIMM/LRDIMM)

  • Speed: 2666 or 2933 MT/s depending on CPU generation

  • Memory Protection: Advanced ECC, Memory Lock step, Online Spare
Storage

  • Front Drive Bays: Flexible chassis options:

    • Up to 12 × LFF (3.5") SAS/SATA HDD/SSD

    • Or up to 24 × SFF (2.5") SAS/SATA/NVMe



  • Optional Rear/Mid-Tray: Additional 2–6 SFF or LFF drives

  • Supported Drive Types: SAS, SATA, NVMe U.2/U.3 via tri mode Smart Array controllers

  • Boot Options: Optional M.2 SATA boot module

  • Front Drive Bays:

    • Up to 12 × LFF (3.5") SAS/SATA hot plug

    • Or up to 24 × SFF (2.5") SAS/SATA/NVMe hot plug



  • Expansion Options: Additional bay trays may support NVMe or hybrid drive layouts

  • RAID Controllers: HPE Smart Array P408i a SR, P816i a SR, E208i a, P824i p, etc.

  • Boot Options: Optional M.2 boot module or Smart Array controller-based boot
Expansion / Connectivity

  • PCIe Slots: Up to 8–9 × PCIe 3.0 slots depending on riser configuration

  • Networking: OCP 3.0 mezzanine slot available (for 10/25/100 GbE modules)

  • PCIe Slots: Up to 8 PCIe 3.0 slots in tower chassis for GPU, networking or HBA

  • Networking: Embedded 4 × 1 GbE NIC; optional Flexible LOM (OCP-style mezzanine) available
Redundancy & Reliability

  • Power Supplies: Redundant Flex Slot power supplies (e.g., 800 W, 1600 W Platinum)

  • Cooling: Hot-plug fans; high-performance kit required for NVMe, GPU or high-TDP CPU setups

  • RAID Controllers: HPE Smart Array P408i-a SR (Gen10) and other Gen10 tri mode controllers

  • Power Supplies: Standard 500 W or 800 W non hot plug PSU; optional redundant 500 W or 800 W Flex Slot PSUs

  • Cooling: Standard 4 fans; optional redundant fan cage for GPU or NVMe heavy configs

  • Security Features: TPM 2.0 module support, iLO Secure Boot, chassis padlock and bezel lock
Operating System Support

  • Microsoft Windows Server 2016 / 2019 / 2022

  • Red Hat Enterprise Linux (RHEL)

  • SUSE Linux Enterprise Server (SLES)

  • VMware ESXi (vSphere 6.7 U3, 7.x, 8.x)

  • Additional: Ubuntu, Oracle Linux, Citrix XenServer

  • Microsoft Windows Server 2016 / 2019 / 2022

  • Red Hat Enterprise Linux (RHEL)

  • SUSE Linux Enterprise Server (SLES)

  • VMware ESXi (vSphere 6.7 U3, 7.x, 8.x)

  • Other: Ubuntu, Oracle Linux, Citrix XenServer
Security Features

  • iLO 5 Security: Server Configuration Lock, BIOS Advisor, iLO Security Dashboard

  • Secure Boot & Secure Erase: Supported via system firmware

  • TPM 2.0 Support: Optional module available

  • Silicon Secured Boot: iLO 5 system configuration lock, BIOS advisor, secure recovery

  • Encryption: TPM 2.0 support, secure erase, firmware rollback, AES/3DES encryption
Management & Monitoring

  • Integrated Lights Out (iLO 5): Remote management, firmware control, health alerts

  • Management Tools: HPE Intelligent Provisioning, InfoSight, OneView Standard

  • APIs: Redfish, RESTful API, SNMP v3, IPMI 2.0

  • Integrated Lights Out (iLO 5): Full remote console, firmware updates, health monitoring

  • Management Tools: HPE Intelligent Provisioning, OneView, InfoSight

  • API Support: Redfish, RESTful, IPMI 2.0, SNMP v3
Warranty & Support

  • Standard Warranty: 3-Year Parts, 3-Year Labor, 3-Year Onsite (Next Business Day)

  • Optional Services: HPE Pointnext Tech Care, Foundation Care, Proactive Care

  • Standard Warranty: 3 Year Parts, 3 Year Labor, 3 Year Onsite (Next Business Day)

  • Optional Services: HPE Foundation Care, Proactive Care, Pointnext Tech Care

Key Features Comparison

Powerful Performance for Diverse Workloads:
Equipped with Intel® Xeon® Scalable processors, the DL380 Gen10 delivers reliable, high-performance processing for various business applications.
Versatile Storage Options:
Supports a range of storage configurations, from SATA and SAS to ultra-fast NVMe drives, providing flexibility to match your data needs and business growth.
Advanced Security Features
Incorporates HPE’s Silicon Root of Trust technology, offering a secure boot and robust protection against unauthorized firmware changes.
Scalable Architecture and Expansion Flexibility:
With PCIe slots, the DL380 Gen10 offers enhanced flexibility, allowing easy expansion for evolving IT infrastructure and workload demands.
Energy Efficient Design:
Designed to reduce power consumption while maintaining high performance, helping lower operational costs and supporting eco-friendly objectives.
Reliable Redundancy and Fault Tolerance:
Dual power supplies and redundant fans maximize uptime, ensuring continuous operation in mission-critical environments.
Powerful Scalability:
Powered by Intel® Xeon® Scalable processors, the ML350 Gen10 offers robust, enterprise-level performance, making it an ideal choice for organizations with growing data needs.
Flexible Expansion Options:
Supports a broad range of storage configurations, from SATA HDDs to high-speed NVMe SSDs, with the capability to add up to 24 drive bays and 12 DIMM slots for versatile storage and memory expansion.
Enhanced Security and Reliability:
Features HPE’s Silicon Root of Trust technology to safeguard firmware against threats, along with robust redundancy features like dual power supplies to minimize downtime.
Advanced Management with HPE iLO 5:
HPE Integrated Lights-Out (iLO 5) simplifies server management with remote monitoring and diagnostic tools, making it easier to maintain and secure your IT infrastructure.
Energy Efficient Design:
Optimized for low power consumption, the ML350 Gen10 helps reduce operational costs, making it a cost-effective solution for high-performance needs.
Tower or Rack Mount Flexibility:
With the ability to be configured as a tower or rack-mount server, it’s adaptable to various deployment environments, from data centers to office setups.

HPE ProLiant DL380 Gen10 Server vs HPE ProLiant ML350 Gen10 Server : Which should I choose?

Choosing the right server is a critical decision for any business, and comparing HPE ProLiant DL380 Gen10 Server and HPE ProLiant ML350 Gen10 Server gives you clear insights into which solution aligns best with your IT requirements. These servers are built for high performance, but they may differ in areas such as processor capacity, memory, storage, and scalability, making a side-by-side comparison easy.

This direct comparison helps you quickly identify the strengths and limitations of each server, which helps you determine which model best supports your workloads, applications, and long-term IT goals. By evaluating them together, you can make a smarter investment that ensures reliability and efficiency for your business.

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